RT @MaraMather
Now publicly available, a dataset (N>150) with resting-state fMRI, PCASL, MRS, and emotion regulation and decision tasks + physiological measures (HRV, blood pressure, pulse, respiration, and end-tidal CO2): https://www.medrxiv.org/content/10.1101/2022.12.28.22283798v1 #neuroscience #HRV
medRxivMultimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trialWe present data from the Heart Rate Variability and Emotion Regulation (HRV-ER) randomized clinical trial testing effects of HRV biofeedback. Younger (N = 121, ages 18-31, 61 female) and older (N = 72, ages 55-80, 45 female) participants completed baseline magnetic resonance imaging (MRI) including T1-weighted, functional MRI (fMRI), pulsed continuous arterial spin labeling (PCASL), and proton magnetic resonance spectroscopy (1H MRS). They also completed an emotion regulation task during fMRI. During fMRI scans, physiological measures (blood pressure, pulse, respiration, and end-tidal CO2) were continuously acquired. Participants were randomized to either increase heart rate oscillations or decrease heart rate oscillations during daily sessions. After 5 weeks of HRV biofeedback, they repeated the baseline measurements in addition to a few new measures (ultimatum game fMRI, training mimicking during blood oxygen level dependent (BOLD) and PCASL fMRI). Participants also wore a wristband sensor to estimate sleep time. Psychological assessment comprised three cognitive tests as well as ten questionnaires related to emotional well-being. Data is publicly available via the OpenNeuro data sharing platform.
### Competing Interest Statement
The authors have declared no competing interest.
### Clinical Trial
NCT03458910
### Funding Statement
This study was funded by NIH R01AG025340 and R01AG057184
### Author Declarations
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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
The University of Southern California Institutional Review Board gave ethical approval for this work.
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The data described in this paper are available on the OpenNeuro data sharing platform (<https://openneuro.org/datasets/ds003823>)
<https://openneuro.org/datasets/ds003823>