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The Novavax study provides a good example of how memory B cells will recall antibodies for specific variants it has been exposed to before. The original vaccine (Prototype) on its own (left side) produces antibodies with high levels of neutralization for the original variant (first column) , but low levels for XBB.1.5 (third column). Similarly on the right side, the XBB.1.5 vaccine on its own produces antibodies with low levels of neutralization for the original variant but high for XBB.1.5. 23/