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Jeff Gilchrist

With the NVX.425.6 monoclonal, for the original strain, BA.2 and BA.5 they found no mutations in the RBD which provided very good neutralization. BQ.1.1 has a mutation in K444T and XBB has mutations in K445P and G446S and these structural changes result in decreased binding and lower neutralization from Novavax elicited antibodies. 16/