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Jeff Gilchrist

Trying to determine why the original Novavax vaccine elicits much lower neutralization with BQ.1.1 and XBB, they used their own monoclonal antibody designs to determine where binding failed. Their images show the Spike protein in blue, the Receptor Binding Domain (RBD) in grey, the epitope the antibody binds to in pink, and their antibody in green/yellow. 15/

Slide showing mutations in conserved RBD epitope impact monoclonal antibody binding and neutralization where BQ.1.1 and XBB variants have multiple mutations
Feb 04, 2023, 03:46 PM·Quiet public·Web
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