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Talmudic Question #205

There are plenty of natural product families that inhibit essential enzymatic functions in cell wall synthesis (e.g., ß-lactams, glycopeptides), translation (e.g., aminoglycosides, tetracyclines) and transcription (e.g. rifampicin). Yet, there are very few (if any) natural products that specifically inhibit bacterial DNA polymerase. Why have such compounds not been found?

Read more → https://schaechter.asmblog.org/schaechter/2023/07/talmudic-question-205.html