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Emergence of a new #genotype of clade 2.3.4.4b #H5N1 highly pathogenic #avian #influenza A viruses in #Bangladesh, Emerg Microbe Infect., https://doi.org/10.1080/22221751.2023.2252510 #epizootic #panzootic #zoonoses #pandemic #research
''We also detected a novel clade 2.3.4.4b #H5N1 virus from #ducks in free-range #farms in Tanguar Haor that was similar to viruses first detected in October 2020 in The #Netherlands but with a different #PB2. ''
''Other well characterized #mammalian-adaptive #substitutions such as #PB2 627 K or 701N were not present in the #H5N1 viruses from #Bangladesh, however, they did contain PB2-655 V, which has been shown to act cooperatively to increase viral #polymerase activity in human cells46,47.''