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Identification of #SARS-CoV-2 #Mpro #inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2 https://www.nature.com/articles/s41467-023-36729-0
NatureIdentification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2 - Nature CommunicationsEffective antivirals are critical for combatting SARS-CoV-2 infections. Here, the authors develop two orally available small molecules, which specifically inhibit the activity of the SARS-CoV-2 main protease and potently block the infectivity and replication of various SARS-CoV-2 strains in cells and mice.