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Giuseppe MichieliHeterogeneity across <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a>- and <a href="https://mstdn.science/tags/avian" class="mention hashtag" rel="tag">#avian</a>-origin A(<a href="https://mstdn.science/tags/H1N1" class="mention hashtag" rel="tag">#H1N1</a>) <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="tag">#influenza</a> viruses influences viral infectivity following incubation with host <a href="https://mstdn.science/tags/bacteria" class="mention hashtag" rel="tag">#bacteria</a> from the human respiratory tract, <a href="https://etidiohnew.blogspot.com/2025/03/heterogeneity-across-mammalian-and.html" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://etidiohnew.blogspot.com/2025/03/heterogeneity-across-mammalian-and.html</a>

The Krononaut Moon Project 🌑  <a href="https://me.dm/tags/Apes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Apes</a> point out hidden treats only when <a href="https://me.dm/tags/humans" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#humans</a> are <a href="https://me.dm/tags/unaware" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#unaware</a> of their <a href="https://me.dm/tags/location" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#location</a>. ❛❛ It's a <a href="https://me.dm/tags/sign" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sign</a> of a <a href="https://me.dm/tags/cognitive" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cognitive</a> ability called <a href="https://me.dm/tags/Theory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Theory</a> of <a href="https://me.dm/tags/Mind" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mind</a>. ❜❜🔗 <a href="https://www.youtube.com/watch?v=kPD9jqXEv7Y" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.youtube.com/watch?v=kPD9jqXEv7Y</a> 2025 Feb 04 🔗 <a href="https://www.SmithsonianMag.com/smart-news/when-bonobos-know-what-you-dont-theyll-tell-you-its-a-sign-of-a-cognitive-ability-called-theory-of-mind-180985991/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.SmithsonianMag.com/smart-news/when-bonobos-know-what-you-dont-theyll-tell-you-its-a-sign-of-a-cognitive-ability-called-theory-of-mind-180985991/</a> 2025 Feb 05 🔗 <a href="https://en.Wikipedia.org/wiki/Theory_of_mind" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://en.Wikipedia.org/wiki/Theory_of_mind</a> … <a href="https://me.dm/tags/TheoryOfMind" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TheoryOfMind</a> <a href="https://me.dm/tags/Community" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Community</a> <a href="https://me.dm/tags/TimeTravel" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TimeTravel</a> <a href="https://me.dm/tags/Research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Research</a> <a href="https://me.dm/tags/primates" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#primates</a> <a href="https://me.dm/tags/mammalian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mammalian</a> <a href="https://me.dm/tags/intelligence" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#intelligence</a> <a href="https://me.dm/tags/interspecies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interspecies</a> <a href="https://me.dm/tags/communitication" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#communitication</a> <a href="https://me.dm/tags/psychology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#psychology</a> <a href="https://me.dm/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a> <a href="https://me.dm/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#science</a> <a href="https://me.dm/tags/Kronodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Kronodon</a>

CellBioNews'Ball and chain' mechanism inactivates key <a href="https://scientificnetwork.de/tags/mammalian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mammalian</a> <a href="https://scientificnetwork.de/tags/ion_channel" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ion_channel</a>, study finds <a href="https://scientificnetwork.de/tags/potassium" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#potassium</a> <a href="https://scientificnetwork.de/tags/BK_channels" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BK_channels</a> <a href="https://scientificnetwork.de/tags/calcium" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#calcium</a><a href="https://phys.org/news/2025-03-ball-chain-mechanism-inactivates-key.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://phys.org/news/2025-03-ball-chain-mechanism-inactivates-key.html</a>

MidgePhoto<a href="https://sauropods.win/@futurebird" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@futurebird</a> <a href="https://mastodon.social/@falcennial" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@falcennial</a> <a href="https://stranger.social/@AlexanderVI" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@AlexanderVI</a> All advanced species have been eaten by Ants. Hmm.@cstross SF author near here wrote a couple of worlds/SF books in which the eventual winners are or are going to be the <a href="https://photog.social/tags/eusocial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#eusocial</a> species, of which <a href="https://photog.social/tags/ants" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ants</a> and suchlike seem to be examples.Perhaps those winners would not bother to talk to us <a href="https://photog.social/tags/mammalian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mammalian</a> species.

Giuseppe MichieliIsoleucine at position 137 of <a href="https://mstdn.science/tags/Hemagglutinin" class="mention hashtag" rel="tag">#Hemagglutinin</a> acts as a <a href="https://mstdn.science/tags/Mammalian" class="mention hashtag" rel="tag">#Mammalian</a> <a href="https://mstdn.science/tags/adaptation" class="mention hashtag" rel="tag">#adaptation</a> <a href="https://mstdn.science/tags/marker" class="mention hashtag" rel="tag">#marker</a> of <a href="https://mstdn.science/tags/H9N2" class="mention hashtag" rel="tag">#H9N2</a> Avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="tag">#influenza</a> virus, <a href="https://etidiohnew.blogspot.com/2025/01/isoleucine-at-position-137-of.html" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://etidiohnew.blogspot.com/2025/01/isoleucine-at-position-137-of.html</a>

Giuseppe MichieliSusceptibility of <a href="https://mstdn.science/tags/bovine" class="mention hashtag" rel="tag">#bovine</a> respiratory and mammary epithelial <a href="https://mstdn.science/tags/cells" class="mention hashtag" rel="tag">#cells</a> to avian and <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> derived clade 2.3.4.4b <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="tag">#H5N1</a> highly pathogenic avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="tag">#influenza</a> viruses, <a href="https://etidiohnew.blogspot.com/2025/01/susceptibility-of-bovine-respiratory.html" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://etidiohnew.blogspot.com/2025/01/susceptibility-of-bovine-respiratory.html</a>

Giuseppe MichieliA low pathogenic avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="tag">#influenza</a> A/Mallard/South Korea/KNU2019-34/2019 (<a href="https://mstdn.science/tags/H1N1" class="mention hashtag" rel="tag">#H1N1</a>) virus has the potential to increase the <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> <a href="https://mstdn.science/tags/pathogenicity" class="mention hashtag" rel="tag">#pathogenicity</a>, <a href="https://etidiohnew.blogspot.com/2024/12/a-low-pathogenic-avian-influenza.html" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://etidiohnew.blogspot.com/2024/12/a-low-pathogenic-avian-influenza.html</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/Chicken" class="mention hashtag" rel="tag">#Chicken</a> ANP32A-independent <a href="https://mstdn.science/tags/replication" class="mention hashtag" rel="tag">#replication</a> of highly pathogenic avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="tag">#influenza</a> viruses potentially leads to <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> <a href="https://mstdn.science/tags/adaptation" class="mention hashtag" rel="tag">#adaptation</a>-related amino acid substitutions in viral <a href="https://mstdn.science/tags/PB2" class="mention hashtag" rel="tag">#PB2</a> and <a href="https://mstdn.science/tags/PA" class="mention hashtag" rel="tag">#PA</a> proteinsSource: Journal of Virology, ABSTRACTAcidic nuclear phosphoprotein 32 family member A (ANP32A) is an important host factor that supports the efficient replication of avian influenza viruses (AIVs). To develop an antiviral strategy against Gs/Gd-lineage H5 highly pathogenic…<a href="https://etidioh.wordpress.com/2024/11/21/chicken-anp32a-independent-replication-of-highly-pathogenic-avian-influenza-viruses-potentially-leads-to-mammalian-adaptation-related-amino-acid-substitutions-in-viral-pb2-and-pa-proteins/" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://etidioh.wordpress.com/2024/11/21/chicken-anp32a-independent-replication-of-highly-pathogenic-avian-influenza-viruses-potentially-leads-to-mammalian-adaptation-related-amino-acid-substitutions-in-viral-pb2-and-pa-proteins/</a>

Giuseppe MichieliEmerging <a href="https://mstdn.science/tags/Threats" class="mention hashtag" rel="tag">#Threats</a> of Highly Pathogenic Avian <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="tag">#Influenza</a> A (<a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="tag">#H5N1</a>) in <a href="https://mstdn.science/tags/US" class="mention hashtag" rel="tag">#US</a> Dairy <a href="https://mstdn.science/tags/Cattle" class="mention hashtag" rel="tag">#Cattle</a>: Understanding Cross-Species <a href="https://mstdn.science/tags/Transmission" class="mention hashtag" rel="tag">#Transmission</a> Dynamics in <a href="https://mstdn.science/tags/Mammalian" class="mention hashtag" rel="tag">#Mammalian</a> HostsSource: Viruses, AbstractThe rapid geographic spread of the highly pathogenic avian influenza (HPAI) A(H5N1) virus in poultry, wild birds, and other mammalian hosts, including humans, raises significant health concerns globally. The recent emergence of HPAI A(H5N1) in agricultural animals such as cattle and goats…<a href="https://etidioh.wordpress.com/2024/10/30/emerging-threats-of-highly-pathogenic-avian-influenza-a-h5n1-in-us-dairy-cattle-understanding-cross-species-transmission-dynamics-in-mammalian-hosts/" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://etidioh.wordpress.com/2024/10/30/emerging-threats-of-highly-pathogenic-avian-influenza-a-h5n1-in-us-dairy-cattle-understanding-cross-species-transmission-dynamics-in-mammalian-hosts/</a>

Giuseppe MichieliAn emerging <a href="https://mstdn.science/tags/PB2" class="mention hashtag" rel="tag">#PB2</a>-627 <a href="https://mstdn.science/tags/polymorphism" class="mention hashtag" rel="tag">#polymorphism</a> increases <a href="https://mstdn.science/tags/pandemic" class="mention hashtag" rel="tag">#pandemic</a> <a href="https://mstdn.science/tags/potential" class="mention hashtag" rel="tag">#potential</a> of avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="tag">#influenza</a> virus by breaking through ANP32 host restriction in <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> & avian hosts, BioRxIV: <a href="https://www.biorxiv.org/content/10.1101/2024.07.03.601996v4" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.biorxiv.org/content/10.1101/2024.07.03.601996v4</a> by screening the global PB2 seq., we discovered a new independent cluster with PB2-627V emerged in the '10s, which is prevalent in various avian, mammalian, & human isolates of AIVs, including <a href="https://mstdn.science/tags/H9N2" class="mention hashtag" rel="tag">#H9N2</a>, <a href="https://mstdn.science/tags/H7N9" class="mention hashtag" rel="tag">#H7N9</a>, <a href="https://mstdn.science/tags/H3N8" class="mention hashtag" rel="tag">#H3N8</a>, 2.3.4.4b <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="tag">#H5N1</a>, and other subtypes.

Giuseppe Michieli<a href="https://mstdn.science/tags/Infection" class="mention hashtag" rel="tag">#Infection</a> of South American <a href="https://mstdn.science/tags/coatis" class="mention hashtag" rel="tag">#coatis</a> (Nasua nasua) with highly pathogenic avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="tag">#influenza</a> <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="tag">#H5N1</a> virus displaying <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> adaptive <a href="https://mstdn.science/tags/mutations" class="mention hashtag" rel="tag">#mutations</a> <a href="https://pubmed.ncbi.nlm.nih.gov/39208965/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240831114427&v=2.18.0.post9+e462414" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://pubmed.ncbi.nlm.nih.gov/39208965/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240831114427&v=2.18.0.post9+e462414</a> 3 mos after 1rst reported case in <a href="https://mstdn.science/tags/Uruguay" class="mention hashtag" rel="tag">#Uruguay</a>, disease affected a population of 23 coatis in an ecological park. Most animals became infected, likely directly or indirectly from wild birds in park, & experienced sudden death. 5 animals from colony survived, & 4 of them developed antibodies. Genomes of strains belonged to B32 gt.

Giuseppe MichieliDecoding non- <a href="https://mstdn.science/tags/human" class="mention hashtag" rel="tag">#human</a> <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> adaptive <a href="https://mstdn.science/tags/signatures" class="mention hashtag" rel="tag">#signatures</a> of 2.3.4.4b <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="tag">#H5N1</a> to assess its human adaptive <a href="https://mstdn.science/tags/potential" class="mention hashtag" rel="tag">#potential</a>, BioRxIV: <a href="https://www.biorxiv.org/content/10.1101/2024.08.26.609722v1?rss=1" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.biorxiv.org/content/10.1101/2024.08.26.609722v1?rss=1</a> H5N1 infections in mammals across time showed a unique set of adaptations in 2.3.4.4b clade compared to previously circulating strains, especially acquisition of Q591 adaptation in <a href="https://mstdn.science/tags/PB2" class="mention hashtag" rel="tag">#PB2</a> that enables human adaptation.

SICB journals(ICB & IOB)IOB The <a href="https://earthstream.social/tags/Kinematics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Kinematics</a> of Proal Chewing in <a href="https://earthstream.social/tags/rats" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#rats</a> E D McParland, J K Mitchell, J D Laurence-Chasen, L C Aspinwall, O Afolabi, K Takahashi, C F Ross, N J Gidmark, <a href="https://doi.org/10.1093/iob/obae023" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.1093/iob/obae023</a><a href="https://earthstream.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a> <a href="https://earthstream.social/tags/teeth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#teeth</a> <a href="https://earthstream.social/tags/dental" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dental</a> <a href="https://earthstream.social/tags/mammalian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mammalian</a> <a href="https://earthstream.social/tags/organisms" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#organisms</a>

Giuseppe MichieliAn emerging <a href="https://mstdn.science/tags/PB2" class="mention hashtag" rel="tag">#PB2</a>-627 <a href="https://mstdn.science/tags/polymorphism" class="mention hashtag" rel="tag">#polymorphism</a> increases the <a href="https://mstdn.science/tags/pandemic" class="mention hashtag" rel="tag">#pandemic</a> <a href="https://mstdn.science/tags/potential" class="mention hashtag" rel="tag">#potential</a> of avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="tag">#influenza</a> virus by breaking through ANP32 <a href="https://mstdn.science/tags/host" class="mention hashtag" rel="tag">#host</a> <a href="https://mstdn.science/tags/restriction" class="mention hashtag" rel="tag">#restriction</a> in <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> and avian hosts, BioRxIV: <a href="https://www.biorxiv.org/content/10.1101/2024.07.03.601996v3" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.biorxiv.org/content/10.1101/2024.07.03.601996v3</a> ...we discovered a new independent <a href="https://mstdn.science/tags/cluster" class="mention hashtag" rel="tag">#cluster</a> with PB2-627V emerged in the 2010s, which is prevalent in various avian, mammalian, and human isolates of AIVs, including <a href="https://mstdn.science/tags/H9N2" class="mention hashtag" rel="tag">#H9N2</a>, <a href="https://mstdn.science/tags/H7N9" class="mention hashtag" rel="tag">#H7N9</a>, <a href="https://mstdn.science/tags/H3N8" class="mention hashtag" rel="tag">#H3N8</a>, 2.3.4.4b <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="tag">#H5N1</a>, and other subtypes.

Giuseppe Michieli''It is noteworthy that crucial mutations associated with <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> <a href="https://mstdn.science/tags/host" class="mention hashtag" rel="tag">#host</a> <a href="https://mstdn.science/tags/adaptation" class="mention hashtag" rel="tag">#adaptation</a> and enhanced <a href="https://mstdn.science/tags/transmission" class="mention hashtag" rel="tag">#transmission</a>, specifically residues 271A, 292 V, 591 K, 627 K/V/A, 701N, in PB2 (28, 30, 33-35), and 228S, along with the <a href="https://mstdn.science/tags/virulence" class="mention hashtag" rel="tag">#virulence</a>-increasing residue 66S in PB1-F2(46), were conspicuously absent in all <a href="https://mstdn.science/tags/HPAI" class="mention hashtag" rel="tag">#HPAI</a> virus strains derived from dairy <a href="https://mstdn.science/tags/cattle" class="mention hashtag" rel="tag">#cattle</a> and <a href="https://mstdn.science/tags/cats" class="mention hashtag" rel="tag">#cats</a>. ''

Giuseppe MichieliAn emerging <a href="https://mstdn.science/tags/PB2" class="mention hashtag" rel="tag">#PB2</a>-627 <a href="https://mstdn.science/tags/polymorphism" class="mention hashtag" rel="tag">#polymorphism</a> increases the <a href="https://mstdn.science/tags/pandemic" class="mention hashtag" rel="tag">#pandemic</a> <a href="https://mstdn.science/tags/potential" class="mention hashtag" rel="tag">#potential</a> of avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="tag">#influenza</a> virus by breaking through ANP32 <a href="https://mstdn.science/tags/host" class="mention hashtag" rel="tag">#host</a> restriction in <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> and avian <a href="https://mstdn.science/tags/hosts" class="mention hashtag" rel="tag">#hosts</a>, BioRxIV, <a href="https://www.biorxiv.org/content/10.1101/2024.07.03.601996v1?rss=1" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.biorxiv.org/content/10.1101/2024.07.03.601996v1?rss=1</a> The PB2-627V polymorphism has been found in birds, humans, and mammals worldwide across more than ten AIV <a href="https://mstdn.science/tags/subtypes" class="mention hashtag" rel="tag">#subtypes</a>. Given the escalating global spread of AIVs, it is crucial to closely monitor influenza viruses carrying PB2-627V to prevent a pandemic.

Giuseppe MichieliThe virus is out of the <a href="https://mstdn.science/tags/barn" class="mention hashtag" rel="tag">#barn</a>: the emergence of <a href="https://mstdn.science/tags/HPAI" class="mention hashtag" rel="tag">#HPAI</a> as a <a href="https://mstdn.science/tags/pathogen" class="mention hashtag" rel="tag">#pathogen</a> of <a href="https://mstdn.science/tags/avian" class="mention hashtag" rel="tag">#avian</a> and <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> <a href="https://mstdn.science/tags/wildlife" class="mention hashtag" rel="tag">#wildlife</a> around the globe <a href="https://pubmed.ncbi.nlm.nih.gov/38593825/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240502024722&v=2.18.0.post9+e462414" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://pubmed.ncbi.nlm.nih.gov/38593825/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240502024722&v=2.18.0.post9+e462414</a> Active research is focusing on new approaches to understanding the relationship of viral genotype to phenotype and the implementation of research and surveillance pipelines to make sense of the enormous potential for diverse HPAI viruses to emerge from wild reservoirs amid global circulation.

Giuseppe Michieli<a href="https://mstdn.science/tags/Mammalian" class="mention hashtag" rel="tag">#Mammalian</a> <a href="https://mstdn.science/tags/adaptation" class="mention hashtag" rel="tag">#adaptation</a> <a href="https://mstdn.science/tags/risk" class="mention hashtag" rel="tag">#risk</a> in HPAI <a href="https://mstdn.science/tags/H5N8" class="mention hashtag" rel="tag">#H5N8</a>: a comprehensive model bridging experimental data with mathematical insights, Emerg Microbe Infect.: <a href="https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2339949" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2339949</a> By leveraging an integrated non-linear regression model, we quantitatively determined the influence of these markers on growth, adaptation, and RNA expression in mammalian hosts. Furthermore, our findings revealed that the interplay of these markers can lead to synergistic, additive, or antagonistic effects when combined.

Giuseppe Michieli<a href="https://mstdn.science/tags/PB2" class="mention hashtag" rel="tag">#PB2</a> residue 473 contributes to the <a href="https://mstdn.science/tags/mammalian" class="mention hashtag" rel="tag">#mammalian</a> <a href="https://mstdn.science/tags/virulence" class="mention hashtag" rel="tag">#virulence</a> of <a href="https://mstdn.science/tags/H7N9" class="mention hashtag" rel="tag">#H7N9</a> avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="tag">#influenza</a> virus by modulating viral <a href="https://mstdn.science/tags/polymerase" class="mention hashtag" rel="tag">#polymerase</a> activity via ANP32A, J Virol.: <a href="https://doi.org/10.1128/jvi.01944-23" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://doi.org/10.1128/jvi.01944-23</a>-- In this study, we identified PB2 residue 473 as a new determinant of mouse virulence and mammalian <a href="https://mstdn.science/tags/adaptation" class="mention hashtag" rel="tag">#adaptation</a> of the viral polymerase of the H7N9 virus and its non-pathogenic <a href="https://mstdn.science/tags/H9N2" class="mention hashtag" rel="tag">#H9N2</a> counterparts.

Giuseppe MichieliHighly Pathogenic Avian <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="tag">#Influenza</a> A(<a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="tag">#H5N1</a>) Viruses from <a href="https://mstdn.science/tags/Multispecies" class="mention hashtag" rel="tag">#Multispecies</a> <a href="https://mstdn.science/tags/Outbreak" class="mention hashtag" rel="tag">#Outbreak</a>, <a href="https://mstdn.science/tags/Argentina" class="mention hashtag" rel="tag">#Argentina</a>, August 2023, Emerg Infect Dis.: <a href="https://wwwnc.cdc.gov/eid/article/30/4/23-1725_article" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://wwwnc.cdc.gov/eid/article/30/4/23-1725_article</a>-- We report full-genome characterization of HPAI A(H5N1) clade 2.3.4.4b virus from an outbreak among sea lions (August 2023) in Argentina and possible <a href="https://mstdn.science/tags/spillover" class="mention hashtag" rel="tag">#spillover</a> to fur <a href="https://mstdn.science/tags/seals" class="mention hashtag" rel="tag">#seals</a> and <a href="https://mstdn.science/tags/terns" class="mention hashtag" rel="tag">#terns</a>. <a href="https://mstdn.science/tags/Mammalian" class="mention hashtag" rel="tag">#Mammalian</a> <a href="https://mstdn.science/tags/adaptation" class="mention hashtag" rel="tag">#adaptation</a> mutations in virus isolated from marine mammals and a human in Chile were detected in mammalian and avian hosts.

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