Moritz Negwer<p>Wow, TRISCO (née TRIC-DISCO) is out in Science! This cool approach allows imaging of mRNA transcripts throughout the cleared mouse brain. It uses a signal amplification step with in situ Hybridization Chain Reaction (isHCR) and combines it with DISCO-style solvent-based <a href="https://mstdn.science/tags/tissueclearing" class="mention hashtag" rel="tag">#<span>tissueclearing</span></a> to make the brain transparent.</p><p>Whole-brain spatial transcriptional analysis at cellular resolution<br />Kanatani et al., Science 2024<br /><a href="https://doi.org/10.1126/science.adn9947" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">doi.org/10.1126/science.adn994</span><span class="invisible">7</span></a></p><p><a href="https://mstdn.science/tags/neuroscience" class="mention hashtag" rel="tag">#<span>neuroscience</span></a> <a href="https://mstdn.science/tags/lightsheet" class="mention hashtag" rel="tag">#<span>lightsheet</span></a> <a href="https://mstdn.science/tags/microscopy" class="mention hashtag" rel="tag">#<span>microscopy</span></a> <a href="https://mstdn.science/tags/isHCR" class="mention hashtag" rel="tag">#<span>isHCR</span></a> <a href="https://mstdn.science/tags/mRNA" class="mention hashtag" rel="tag">#<span>mRNA</span></a> <a href="https://mstdn.science/tags/TRISCO" class="mention hashtag" rel="tag">#<span>TRISCO</span></a></p>