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#NK

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earthling<p>A woman who stayed the night on the street reads a book while waiting for the constitutional court ruling on President Yoon Suk Yeol’s impeachment in <a href="https://mastodon.social/tags/Seoul" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Seoul</span></a>, <a href="https://mastodon.social/tags/NK" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NK</span></a></p><p>Photograph: Kim Hong-Ji/Reuters </p><p><span class="h-card" translate="no"><a href="https://a.gup.pe/u/photography" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>photography</span></a></span> <br><a href="https://mastodon.social/tags/women" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>women</span></a> <br><a href="https://mastodon.social/tags/reading" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>reading</span></a></p>
Annick<p>Maar nu eerst: het instructieboek bestuderen voor de online kwalificatie van de Nederlandse Kampioenschappen Puzzelen en Sudoku. Deelname staat open voor iedereen die geïnteresseerd is.</p><p>Het zijn sowieso gewoon hele leuke puzzels die je lekker thuis kan printen en oplossen.</p><p>Wil je er meer over weten, tips &amp; tricks, een keer gezellig samen puzzelen, een privé online trainingskamp of weetikveel: trek me aan mijn mouw!</p><p><a href="https://nk.wcpn.nl/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">nk.wcpn.nl/</span><span class="invisible"></span></a></p><p><a href="https://mstdn.social/tags/NK" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NK</span></a> <a href="https://mstdn.social/tags/puzzle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>puzzle</span></a> <a href="https://mstdn.social/tags/sudoku" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sudoku</span></a></p>
Colin from Edinburgh, Oklahoma<p>The AXIS of Evil in a darker colour; the Free World in a lighter colour.<br><a href="https://mastodon.social/tags/USA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>USA</span></a> <a href="https://mastodon.social/tags/Russia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Russia</span></a> <a href="https://mastodon.social/tags/China" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>China</span></a> <a href="https://mastodon.social/tags/Iran" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Iran</span></a> <a href="https://mastodon.social/tags/NK" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NK</span></a></p>
Colin from Edinburgh, Oklahoma<p>This - all of this is the enemy.<br>It is no longer about individual rogue states.<br>That thinking needs to be put to bed.<br><a href="https://mastodon.social/tags/USA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>USA</span></a> <a href="https://mastodon.social/tags/Russia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Russia</span></a> <a href="https://mastodon.social/tags/China" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>China</span></a> <a href="https://mastodon.social/tags/Iran" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Iran</span></a> <a href="https://mastodon.social/tags/NK" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NK</span></a></p>
Colin from Edinburgh, Oklahoma<p>The <a href="https://mastodon.social/tags/USA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>USA</span></a> made a mistake of historic proportions.</p><p>The birds will come home to roost.</p><p><a href="https://mastodon.social/tags/America" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>America</span></a> <a href="https://mastodon.social/tags/Geopolitics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Geopolitics</span></a> <a href="https://mastodon.social/tags/Ukraine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Ukraine</span></a> <a href="https://mastodon.social/tags/Russia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Russia</span></a> <a href="https://mastodon.social/tags/China" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>China</span></a> <a href="https://mastodon.social/tags/Iran" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Iran</span></a> <a href="https://mastodon.social/tags/NK" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NK</span></a><br><a href="https://medium.com/@colingajewski/americas-isolationist-gamble-409f8075ef00" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">medium.com/@colingajewski/amer</span><span class="invisible">icas-isolationist-gamble-409f8075ef00</span></a></p>
MugsysRapSheet 🔩🐑🐘<p>🧵 (16/100) <a href="https://mastodon.social/tags/ReasonsNotToVoteForTrump" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ReasonsNotToVoteForTrump</span></a><br>One of the first things <a href="https://mastodon.social/tags/DarthTraitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>DarthTraitor</span></a> did upon taking office was reveal that we knew the <a href="https://mastodon.social/tags/TopSecret" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TopSecret</span></a> location of every <a href="https://mastodon.social/tags/NK" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NK</span></a> sub to <a href="https://mastodon.social/tags/Russian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Russian</span></a> spies he welcomed into the Oval Office (<a href="https://mastodon.social/tags/Russia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Russia</span></a>, an ally of NK, almost certainly revealed this fact to them right away.)<br><a href="https://mastodon.social/@MugsysRapSheet/111205167773733590" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">mastodon.social/@MugsysRapShee</span><span class="invisible">t/111205167773733590</span></a></p>
Luís de Sousa<p>The last circuit of the <a href="https://mastodon.social/tags/Dutch" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Dutch</span></a> national <a href="https://mastodon.social/tags/Cycling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Cycling</span></a> championships passed mere 5 km for where I (still) live. A great day of Cycling, as a spectator and a recreational rider.</p><p>My <a href="https://mastodon.social/tags/Dutch" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Dutch</span></a> has evolved to the point someone took me far a Belgian 😀, I guess from Wallonia.</p><p><a href="https://mastodon.social/tags/NK" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NK</span></a> <a href="https://mastodon.social/tags/Wielrennen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Wielrennen</span></a></p>
O'Sullivan Lab<p>We have recently found that <a href="https://mstdn.science/tags/NK" class="mention hashtag" rel="tag">#<span>NK</span></a> cell effector function is sexually dimorphic. How? Female NK cells in mice and human express higher levels of the epigenetic regulator <a href="https://mstdn.science/tags/UTX" class="mention hashtag" rel="tag">#<span>UTX</span></a>, which escapes X-linked inactivation. UTX regulates the chromatin accessibility of <a href="https://mstdn.science/tags/IFNg" class="mention hashtag" rel="tag">#<span>IFNg</span></a> and <a href="https://mstdn.science/tags/Csf2" class="mention hashtag" rel="tag">#<span>Csf2</span></a>, making female NK cells more potent in response to <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="tag">#<span>cytokines</span></a> and <a href="https://mstdn.science/tags/viral" class="mention hashtag" rel="tag">#<span>viral</span></a> infection. </p><p><a href="https://www.nature.com/articles/s41590-023-01463-8" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41590-023</span><span class="invisible">-01463-8</span></a></p>
O'Sullivan Lab<p>We now know that circulating <a href="https://mstdn.science/tags/NK" class="mention hashtag" rel="tag">#<span>NK</span></a> cells can become tissue-resident following infection. Function is to limit <a href="https://mstdn.science/tags/autoimmunity" class="mention hashtag" rel="tag">#<span>autoimmunity</span></a> through <a href="https://mstdn.science/tags/TRAIL" class="mention hashtag" rel="tag">#<span>TRAIL</span></a> mediated elimination of CD4+ T cells in sites of viral persistence. Team science is the best science! </p><p><a href="https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">cell.com/immunity/fulltext/S10</span><span class="invisible">74-7613(23)00026-2</span></a></p>
Carolyn King<p><a href="https://mstdn.science/tags/NK" class="mention hashtag" rel="tag">#<span>NK</span></a> cell memory to <a href="https://mstdn.science/tags/bacterial" class="mention hashtag" rel="tag">#<span>bacterial</span></a> <a href="https://mstdn.science/tags/infection" class="mention hashtag" rel="tag">#<span>infection</span></a> <span class="h-card" translate="no"><a href="https://cuicui.senpaga.net/users/institutpasteur" class="u-url mention">@<span>institutpasteur</span></a></span> <br />Streptococcus pneumoniae drives specific and lasting Natural Killer cell memory | bioRxiv</p><p><a href="https://www.biorxiv.org/content/10.1101/2023.01.26.525815v1" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">23.01.26.525815v1</span></a></p>
O'Sullivan Lab<p>Happy to collaborate on this study profiling the existence and development of cross-tissue <a href="https://mstdn.science/tags/ILC1" class="mention hashtag" rel="tag">#<span>ILC1</span></a> in humans. </p><p><a href="https://doi.org/10.1016/j.celrep.2022.111937" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">doi.org/10.1016/j.celrep.2022.</span><span class="invisible">111937</span></a></p><p>Key Takeaways: </p><p>-Human ILC1 are rare in healthy liver, but accumulate in cirrhotic livers. </p><p>-Unknown <a href="https://mstdn.science/tags/LSEC" class="mention hashtag" rel="tag">#<span>LSEC</span></a>-derived signals + <a href="https://mstdn.science/tags/TGF%CE%B21" class="mention hashtag" rel="tag">#<span>TGFβ1</span></a> + <a href="https://mstdn.science/tags/il7" class="mention hashtag" rel="tag">#<span>il7</span></a> drive differentiation of ILC progenitors to ILC1.</p><p>-Human <a href="https://mstdn.science/tags/NK" class="mention hashtag" rel="tag">#<span>NK</span></a> cells do not differentiate to ILC1 under multiple conditions ex vivo.</p><p>-Human ILC1 make <a href="https://mstdn.science/tags/il2" class="mention hashtag" rel="tag">#<span>il2</span></a> but functional relevance of this still unknown.</p>
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