Gunning Group<p>The mystery of @genentech&#39;s monovalent BRD degraders equipped with a propargyl &quot;degradation tail&quot; has been solved by researchers @abbvie: a <a href="https://mstdn.science/tags/CRISPR" class="mention hashtag" rel="tag">#<span>CRISPR</span></a> screen reveals molecular glue-like recruitment of <a href="https://mstdn.science/tags/DCAF16" class="mention hashtag" rel="tag">#<span>DCAF16</span></a>.<br /><a href="https://mstdn.science/tags/TargetedProteinDegradation" class="mention hashtag" rel="tag">#<span>TargetedProteinDegradation</span></a> <a href="https://mstdn.science/tags/MonovalentDegraders" class="mention hashtag" rel="tag">#<span>MonovalentDegraders</span></a><br /><a href="https://pubs.acs.org/doi/full/10.1021/acschembio.2c00747" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">pubs.acs.org/doi/full/10.1021/</span><span class="invisible">acschembio.2c00747</span></a></p>