New study shows that the monkeypox virus (MPXV) can infect neuronal cells in brain organoids and cause their death: https://mediarelations.unibe.ch/media_releases/2025/media_releases_2025/can_the_monkeypox_virus_infect_the_human_brain/index_eng.html.
This previously unexplored aspect of #MPXV was discovered by a research team from the #IVI, #unibern, #CHUV and the #BundeslaborSpiez.
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Neue Studie zeigt: Das Affenpockenvirus (MPXV) kann neuronale Zellen in Hirnorganoiden infizieren und deren Tod verursachen: https://mediarelations.unibe.ch/medienmitteilungen/2025/medienmitteilungen_2025/kann_das_affenpockenvirus_das_menschliche_gehirn_infizieren/index_ger.html.
Diese bisher unerforschten Aspekte von #MPXV hat ein Forschungsteam des #IVI, #unibern, #CHUV und des #Bundeslabor Spiez entdeckt.
R to @ECDC_EU: First instances of confirmed transmission of #MPXV clade I among close contacts of imported cases within the EU/EEA have been reported by Germany & Belgium.
ECDC is in contact with public health authorities in these countries regarding this development.
https://bit.ly/40I19lD
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https://nitter.privacydev.net/ECDC_EU/status/1879195147097030679#m
European Centre for Disease Prevention and Control · Transmission of monkeypox virus clade I: overall risk remains low in the EU/EEAThe first instances of confirmed transmission of monkeypox virus (MPXV) clade I among close contacts of imported cases within the EU/EEA have been reported by Germany and Belgium.
RT by @ECDC_EU: Illustrating the complexity of #mpox outbreaks:
in their rapid communication @tonywawinab et al. describe co-circulation in Kinshasa of the two distinct #MPXV subclades Ia and Ib between July and August 2024
@sofoniaskt @inrb_kinshasa @Eddy_Lusamaki_K
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.38.2400592
[2024-09-23 10:18 UTC]
#Mpox – #Africa Region, #WHO D.O.N.: https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON528
The clade Ib #MPXV #outbreak, which began in September 2023 in #DRC, is having an increasing number of cases in country & also expanding to neighbouring countries. #Burundi, #Kenya, #Rwanda and #Uganda have each reported their first mpox cases.
www.who.intMpox – African Region
Mpox Disease: The Antiviral Tecovirimat (TPOXX) Found Ineffective in Clinical Trial
The monkeypox virus (MPXV), called so because of its first discovery in monkeys kept in research facility in Denmark, is closely related to variola...........
#antiviral #AntiviralDrug #DRCongo #monkeypox #monkeypoxvirus #Mpox #MPXV #Tecovirimat
Umesh Prasad
Scientific European · Mpox Disease: The Antiviral Tecovirimat (TPOXX) Found Ineffective in Clinical TrialThe monkeypox virus (MPXV), called so because of its first discovery in monkeys kept in research facility in Denmark, is closely related to variola virus that c
"The estimated minimum sizes of respiratory particles carrying MPXV, based on reported viral loads in respiratory fluids, are sufficiently small to generate viral aerosols."
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00059-9/fulltext
#Alerta Epidemiológica #Viruela símica (#MPXV clado I), 8 de agosto del 2024 https://reliefweb.int/report/world/alerta-epidemiologica-viruela-simica-mpxv-clado-i-8-de-agosto-del-2024
...La Organización Panamericana de la Salud / Organización Mundial de la Salud (OPS/OMS) alienta a los Estados Miembros a que se mantengan vigilantes ante la posibilidad de introducción de esta variante en las Américas, que continúen con sus esfuerzos de vigilancia incluyendo la secuenciación genómica de los casos detectados, con especial énfasis en grupos de mayor riesgo.
#Mpox Caused by #Human-to-Human #Transmission of #MPXV in #DRC with Spread to Neighboring #Countries, #US CDC #HAN #Update: https://emergency.cdc.gov/han/2024/han00513.asp?ACSTrackingID=USCDC_511-DM133680&ACSTrackingLabel=HAN%20513%20-%20General%20Public&deliveryName=USCDC_511-DM133680
In late July 24, #Burundi, #Rwanda, & #Uganda reported confirmed cases of mpox, with some cases having linkages to DRC. Rwanda & Uganda have confirmed these cases are due to clade I MPXV; in Burundi, clade-specific testing is underway, but cases are presumed to be clade I due to DRC’s proximity. Mpox is not known to be endemic in these countries.
emergency.cdc.govHealth Alert Network (HAN) - 00513 | Mpox Caused by Human-to-Human Transmission of Monkeypox Virus in the Democratic Republic of the Congo with Spread to Neighboring CountriesHealth Alert Network (HAN). Provided by the Centers for Disease Control and Prevention (CDC).
Wonderful to see this fantastic work on MPXV by @AineOToole @richardneher & a long list of other great scientists. They show #MPXV was circulating in humans undetected for years before the recent outbreak.
And great reporting from Ian Sample & @TheGuardian
https://www.theguardian.com/world/2023/nov/02/mpox-monkeypox-circulated-global-explosion-in-2022
The Guardian · Mpox circulated for five years before global explosion in 2022, research finds
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Great work on #mpox #virus ( #MonkeyPox) from Lisa Bauer, Debby van Riel, & Oliver Harschnitz:
"We found that MPXV infects and replicates more efficiently in astrocytes and microglia compared to cortical neurons, which unlike glial cells showed activation of distinct antiviral programs that may confer differential susceptibility to #MPXV."
from:
"Dissecting the neurotropism and neurovirulence of MPXV using human stem cell-based models"
https://doi.org/10.1101/2023.08.25.554849
bioRxivDissecting the neurotropism and neurovirulence of MPXV using human stem cell-based modelsMpox, formerly known as monkeypox, is a zoonotic illness of international concern that can lead to severe disease including neurological sequelae. However, it remains unclear what the neurotropism of monkeypox virus (MPXV) is and how MPXV infection leads to neurological deficits. Here, we determined the neurotropism and neurovirulence of MPXV using human pluripotent stem cell- (hPSC)-derived neural stem cells, astrocytes, cortical neurons, and microglia together with ex vivo human brain tissue. We found that MPXV infects and replicates more efficiently in astrocytes and microglia compared to cortical neurons, which unlike glial cells showed activation of distinct antiviral programs that may confer differential susceptibility to MPXV. Ex vivo infection of human brain tissue confirmed the susceptibility of astrocytes to MPXV infection, which also had the strongest disease-associated changes. Molecular pathway analyses revealed induction of cellular senescence and a senescence-associated secretory phenotype upon MPXV infection in astrocytes. Finally, we demonstrated that antiviral treatment using tecovirimat inhibits MPXV replication and prevents virus-induced senescence in hPSC-derived astrocytes. Altogether, leveraging hPSC-derived brain cells, we reveal MPXV-induced cell type-specific effects at the molecular and cellular level, which provide important insights into the neuropathogenesis of MPXV infection.
### Competing Interest Statement
The authors have declared no competing interest.
Continued thread
7/6
Interesting report on #Mpox #virus:
(AKA #MonkeyPox or #MPXV)
"We monitored SARS-CoV-2 & MPXV genomes in the air... in Madrid nightclubs... in 2022.
...
MPXV in the air had increased considerably on Aug 8, with 57% of positive samples containing more than 100 genomes per [cubic meter]; this date coincided with the peak incidence of mpox in Spain."
The authors suggest that air sampling might be a useful surveillance method.
#virology #epidemiology #InfectiousDisease
https://doi.org/10.1016/S2666-5247(23)00104-0