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#ExplantModel

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Joseph P.<p>They also suggest that the local presence of multiple layers of <span class="h-card" translate="no"><a href="https://a.gup.pe/u/immune" class="u-url mention">@<span>immune</span></a></span> subversion in cancers depends on the individual tissue, <span class="h-card" translate="no"><a href="https://a.gup.pe/u/treatment" class="u-url mention">@<span>treatment</span></a></span> , tumor type, and the difference between primary <a href="https://mstdn.science/tags/tumor" class="mention hashtag" rel="tag">#<span>tumor</span></a> and metastatic lesion. The authors also found that the results of the <span class="h-card" translate="no"><a href="https://a.gup.pe/u/clinicaltrial" class="u-url mention">@<span>clinicaltrial</span></a></span> were in line with the results of a fully human organotypic tumor <a href="https://mstdn.science/tags/ExplantModel" class="mention hashtag" rel="tag">#<span>ExplantModel</span></a>, which is a simple model with a straightforward approach.</p>
Joseph P.<p>In other words, the tumor cells are using the host&#39;s immune cells to help them grow and spread.</p><p>the effects of CCR5 blockade on the <span class="h-card" translate="no"><a href="https://a.gup.pe/u/tissue" class="u-url mention">@<span>tissue</span></a></span> level. </p><p>Tumor <span class="h-card" translate="no"><a href="https://a.gup.pe/u/cell" class="u-url mention">@<span>cell</span></a></span> death and a specific pattern of <a href="https://mstdn.science/tags/cytokine" class="mention hashtag" rel="tag">#<span>cytokine</span></a> and <a href="https://mstdn.science/tags/chemokine" class="mention hashtag" rel="tag">#<span>chemokine</span></a> modulation are observed in the <a href="https://mstdn.science/tags/ExplantModel" class="mention hashtag" rel="tag">#<span>ExplantModel</span></a> and in <span class="h-card" translate="no"><a href="https://a.gup.pe/u/tumor" class="u-url mention">@<span>tumor</span></a></span> biopsies from a <a href="https://mstdn.science/tags/ClinicalTrial" class="mention hashtag" rel="tag">#<span>ClinicalTrial</span></a>. Macrophages are the key for these anti-tumoral effects, as they produce IFNs and reactive oxygen species which cause tumor cell death.</p>
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