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#BiomolecularCondensates

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Victoria Stuart 🇨🇦 🏳️‍⚧️<p>TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis<br><a href="https://www.nature.com/articles/s41556-021-00641-w" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41556-021</span><span class="invisible">-00641-w</span></a></p><p>-------------</p><p>Understudied protein blobs have global effects on cell biochemistry<br><a href="https://phys.org/news/2024-09-understudied-protein-blobs-global-effects.html" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">phys.org/news/2024-09-understu</span><span class="invisible">died-protein-blobs-global-effects.html</span></a><br><a href="https://news.ycombinator.com/item?id=41602473" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">news.ycombinator.com/item?id=4</span><span class="invisible">1602473</span></a></p><p>Biomolecular condensates regulate cellular electrochemical equilibria<br><a href="https://www.cell.com/cell/abstract/S0092-8674(24)00909-7" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">cell.com/cell/abstract/S0092-8</span><span class="invisible">674(24)00909-7</span></a></p><p><a href="https://mastodon.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>biology</span></a> <a href="https://mastodon.social/tags/biochemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>biochemistry</span></a> <a href="https://mastodon.social/tags/electrochemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>electrochemistry</span></a> <a href="https://mastodon.social/tags/ProteinChemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ProteinChemistry</span></a> <a href="https://mastodon.social/tags/BiomolecularCondensates" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BiomolecularCondensates</span></a> <a href="https://mastodon.social/tags/MolecularBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MolecularBiology</span></a> <a href="https://mastodon.social/tags/PhaseSeparation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PhaseSeparation</span></a> <a href="https://mastodon.social/tags/PhaseLocalization" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PhaseLocalization</span></a> <a href="https://mastodon.social/tags/ProteinBlobs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ProteinBlobs</span></a></p>
Victoria Stuart 🇨🇦 🏳️‍⚧️<p>A Newfound Source of Cellular Order in the Chemistry of Life<br>Inside cells, droplets of biomolecules called condensates merge, divide and dissolve<br>Their dance may regulate vital processes<br><a href="https://www.quantamagazine.org/a-newfound-source-of-cellular-order-in-the-chemistry-of-life-20210107" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">quantamagazine.org/a-newfound-</span><span class="invisible">source-of-cellular-order-in-the-chemistry-of-life-20210107</span></a></p><p><a href="https://mastodon.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>biology</span></a> <a href="https://mastodon.social/tags/biochemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>biochemistry</span></a> <a href="https://mastodon.social/tags/ProteinChemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ProteinChemistry</span></a> <a href="https://mastodon.social/tags/BiomolecularCondensates" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BiomolecularCondensates</span></a> <a href="https://mastodon.social/tags/MolecularBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MolecularBiology</span></a> <a href="https://mastodon.social/tags/PhaseSeparation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PhaseSeparation</span></a> <a href="https://mastodon.social/tags/PhaseLocalization" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PhaseLocalization</span></a> <a href="https://mastodon.social/tags/ProteinDroplets" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ProteinDroplets</span></a></p>
Victoria Stuart 🇨🇦 🏳️‍⚧️<p>[thread] Biomolecular condensates<br><a href="https://en.wikipedia.org/wiki/Biomolecular_condensate" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">en.wikipedia.org/wiki/Biomolec</span><span class="invisible">ular_condensate</span></a></p><p>* biochemistry - biomolecular condensate: membrane-less subcellular domains<br>* specialized cellular functions<br>* composition not controlled by bounding membrane<br>* form/maintain organization by var. processes<br>* phase separation of proteins, RNA, biopolymers into colloidal emulsions, gels, liquid crystals, solid crystals, aggregates</p><p><a href="https://mastodon.social/tags/biochemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>biochemistry</span></a> <a href="https://mastodon.social/tags/ProteinChemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ProteinChemistry</span></a> <a href="https://mastodon.social/tags/BiomolecularCondensates" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BiomolecularCondensates</span></a> <a href="https://mastodon.social/tags/PhaseSeparation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PhaseSeparation</span></a> <a href="https://mastodon.social/tags/PhaseLocalization" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PhaseLocalization</span></a> <a href="https://mastodon.social/tags/ProteinDroplets" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ProteinDroplets</span></a></p>
Janet Kumita<p>Hello! I am an MRC CDA fellow in the Pharmacology department at the University of Cambridge. Me and my research group are fascinated by the molecular mechanisms that underlie protein self-assembly. We work on strategies to prevent amyloid formation and we are using engineered biomolecular condensates to gain insights into how Nature utilises phase separation to facilitate protein degradation. <a href="https://mstdn.science/tags/neurodegeneration" class="mention hashtag" rel="tag">#<span>neurodegeneration</span></a> <a href="https://mstdn.science/tags/BiomolecularCondensates" class="mention hashtag" rel="tag">#<span>BiomolecularCondensates</span></a> <a href="https://mstdn.science/tags/proteindegradation" class="mention hashtag" rel="tag">#<span>proteindegradation</span></a> <a href="https://mstdn.science/tags/introduction" class="mention hashtag" rel="tag">#<span>introduction</span></a> <a href="https://mstdn.science/tags/Proteindesign" class="mention hashtag" rel="tag">#<span>Proteindesign</span></a></p>
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