mstdn.science

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Stephan HackerThe flash talk session and the posters were a highlight of <a href="https://mstdn.science/tags/ABPP2025" class="mention hashtag" rel="tag">#ABPP2025</a>. We heard a lot of exciting research into <a href="https://mstdn.science/tags/covalent" class="mention hashtag" rel="tag">#covalent</a> <a href="https://mstdn.science/tags/fragment" class="mention hashtag" rel="tag">#fragment</a> screening, <a href="https://mstdn.science/tags/antibiotic" class="mention hashtag" rel="tag">#antibiotic</a> development, <a href="https://mstdn.science/tags/microbiome" class="mention hashtag" rel="tag">#microbiome</a> activities, posttranslational modifications <a href="https://mstdn.science/tags/PTMs" class="mention hashtag" rel="tag">#PTMs</a> and lysine-directed <a href="https://mstdn.science/tags/kinase" class="mention hashtag" rel="tag">#kinase</a> inhibitors. <a href="https://mstdn.science/tags/ABPP" class="mention hashtag" rel="tag">#ABPP</a> <a href="https://mstdn.science/tags/Chemistry" class="mention hashtag" rel="tag">#Chemistry</a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="tag">#ChemBio</a>

Stephan HackerLooking forward to the <a href="https://mstdn.science/tags/ABPP2025" class="mention hashtag" rel="tag">#ABPP2025</a> meeting in London starting this weekend. An amazing lineup of world-leading speakers in the field from academia and industry!If you are there on Saturday or Sunday morning and want to catch up, send me a message!<a href="https://mstdn.science/tags/ABPP" class="mention hashtag" rel="tag">#ABPP</a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="tag">#ChemBio</a><a href="https://www.eventcreate.com/e/abpp2025/" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.eventcreate.com/e/abpp2025/</a>

Stephan HackerHe then zoomed in on protein S-palmitoylation as the main modification that his group is interested in. In this context, he introduced the power of <a href="https://mstdn.science/tags/ABPP" class="mention hashtag" rel="tag">#ABPP</a> to study this modification. (3/5) <a href="https://pubs.acs.org/doi/full/10.1021/acs.jproteome.3c00151" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://pubs.acs.org/doi/full/10.1021/acs.jproteome.3c00151</a>

Stephan HackerInspiring keynote lecture by Uwe Grether of Roche at the <a href="https://mstdn.science/tags/Lunteren" class="mention hashtag" rel="tag">#Lunteren</a> meeting of the <a href="https://mstdn.science/tags/SOC" class="mention hashtag" rel="tag">#SOC</a> and <a href="https://mstdn.science/tags/MCCB" class="mention hashtag" rel="tag">#MCCB</a> divisions of KNCV. He talked about the impressive story of developing MAGL inhibitors into the clinics through a huge diversity of technologies including <a href="https://mstdn.science/tags/ABPP" class="mention hashtag" rel="tag">#ABPP</a>, <a href="https://mstdn.science/tags/AI" class="mention hashtag" rel="tag">#AI</a>, <a href="https://mstdn.science/tags/LSF" class="mention hashtag" rel="tag">#LSF</a> and <a href="https://mstdn.science/tags/HTE" class="mention hashtag" rel="tag">#HTE</a>.

Stephan HackerIf you are looking for exciting scientific content (with a focus on <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="tag">#ChemBio</a>, <a href="https://mstdn.science/tags/Chemistry" class="mention hashtag" rel="tag">#Chemistry</a>, <a href="https://mstdn.science/tags/ABPP" class="mention hashtag" rel="tag">#ABPP</a>, <a href="https://mstdn.science/tags/ChemicalProteomics" class="mention hashtag" rel="tag">#ChemicalProteomics</a>) over on bluesky, check out these starter packs: short list: <a href="https://go.bsky.app/C4URhFa" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://go.bsky.app/C4URhFa</a> pack 1: <a href="https://go.bsky.app/3SyoVNw" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://go.bsky.app/3SyoVNw</a> pack 2: <a href="https://go.bsky.app/9keb2TP" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://go.bsky.app/9keb2TP</a>

Stephan HackerInteresting preprint <a href="https://qoto.org/@biorxivpreprint" class="u-url mention">@biorxivpreprint</a> by the group of <a href="https://mstdn.science/@DanNomura" class="u-url mention">@DanNomura</a>. They put an electrophilic handle on the CDK4/6 inhibitor Ribociclib and show that it converts it into a <a href="https://mstdn.science/tags/proteindegrader" class="mention hashtag" rel="tag">#proteindegrader</a> <a href="https://mstdn.science/tags/TPD" class="mention hashtag" rel="tag">#TPD</a>. Using <a href="https://mstdn.science/tags/ABPP" class="mention hashtag" rel="tag">#ABPP</a> <a href="https://mstdn.science/tags/ChemicalBiology" class="mention hashtag" rel="tag">#ChemicalBiology</a>, they identify RNF126 as responsible E3 ligase. Furthermore, they identify a minimal motif engaging RNF126 and use it to convert various protein ligands into degraders for e.g. CDK4, BCR-ABL and c-ABL, PDE5, BRD4, AR and AR-V7, BTK, SMARCA2, and LRRK2. <a href="https://doi.org/10.1101/2022.11.04.512693" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://doi.org/10.1101/2022.11.04.512693</a>

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