mstdn.science is one of the many independent Mastodon servers you can use to participate in the fediverse.

Administered by:

Server stats:

0
active users

Sterling Ericsson

DICER is one of the fundamental enzymes in your body, responsible for processing RNA into different forms, often involved with RNA silencing.

While we know how double stranded RNAs are processed, how DICER processes microRNAs is poorly understood.

Now, Seoul National University scientists have identified how it utilizes the GYM motif for processing, expanding our fundamental understanding.

nature.com/articles/s41586-023

NatureStructure of the human DICER–pre-miRNA complex in a dicing state - NatureThe active-state structure of human DICER bound to pre-miRNA reveals the structural basis for the specificity of DICER in how it selects substrates in a sequence dependent manner, and sheds light on DICER-related diseases.
Oops!An unexpected error occurred.