Create accountLogin

Recent searches

No recent searches

Search options

Not available on mstdn.science.
mstdn.science is one of the many independent Mastodon servers you can use to participate in the fediverse.
http://mstdn.science is a place for scientists and science enthusiasts to discuss research and topics surrounding our work.

Administered by:

Server stats:

561
active users

mstdn.science: AboutProfiles directoryPrivacy policy

Mastodon: AboutGet the appKeyboard shortcutsView source codev4.3.8

Eric Pyrrhus

1/2
Hmm...

A recent paper looked at evolution of *within* different tissues, which might raise a few questions.

Specifically, the authors found evidence that the might evolve independently in different tissues, especially in immune-privileged sites.

But that's not all...

"High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection"
nature.com/articles/s41467-022

"We use 120 autopsy tissue specimens from six subjects to comprehensively examine SARS-CoV-2 distribution and compartmentalization among tissues, and characterize tissue-specific variants... We identified several extrapulmonary tissues that had high viral loads, some of which had strong genomic evidence for compartmentalized infection." "Compartmentalized infection, particularly in an immune privileged site, may accommodate persistent infections, particularly in immunocompromised individuals, which fosters the generation of many novel mutations. Additionally, these sites could provide a viral reservoir that leads to reactivation or recrudescence." — from (Normandin et al., 2023) https://www.nature.com/articles/s41467-022-34256-y
Apr 02, 2023, 06:22 AM·Public·Web
15boosts·15favorites
ExploreLive feeds
About