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Moritz Negwer

It's long been known that cooling a brain region reduces activity. But this claims that the reverse is also true: pulsed infrared light (1875nm) from a glass fiber locally heating neurons can change their activity. Data looks noisy but this might be interesting if true. (Inclusion into optrodes maybe?)

Two-photon imaging of excitatory and inhibitory neural response to infrared neural stimulation
Fu et al., biorxiv preprint 2024
biorxiv.org/content/10.1101/20

Fig.3. Focal effect of calcium responses to INS. (a) Illustration of the optical fiber placement and the imaging of calcium transients. An optical fiber tilted at an angle of ~45° to the horizontal plane delivers infrared light to the cortex through the cover glass. (b) Theoretical infrared light distribution from a 200 μm core diameter fiber based on a Monte Carlo simulation. (c) Color coding of hSyn neurons spatial distribution map based on amplitude induced by INS. The white dotted box indicates fiber position. The pink dotted conoid indicates the light region. The red box indicates the field of view in two-photon imaging (Near field neuron: n = 40, pink triangle indicates the neuron in light direct exposure areas; Far field neuron: n = 9, gray triangle indicates the 13 / 23 neuron outside light regions). Scale bar, 100 μm. (d-e), A representative example of INS-induced calcium transient in a Near (d, white triangle in c) and Far (e, gray triangle in c) field neuron over different laser radiant exposures, respectively. The pink bar indicates the INS period. Data (n = 6 trials) represents the mean.
#neuroscience#calciumimaging
Mar 05, 2024, 12:40 AM·Public·Web
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