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[Articles] #Safety and #immunogenicity of a purified inactivated #Zika virus #vaccine candidate in adults primed with a Japanese encephalitis virus or yellow fever virus vaccine in the #USA: a phase 1, randomised, double-blind, placebo-controlled clinical trial https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00192-5/fulltext?rss=yes #EID #research #arbovirus
''ZPIV to b well tolerated in #flavivirus naive & primed adults but that immunogenicity varied significantly according 2 antecedent flavivirus #vaccination status. Immune #bias towards flavivirus #antigen of initial exposure & timing of vaccination may have impacted responses. A 3rd ZPIV dose overcame much, but not all, of discrepancy in immunogenicity. Results of this phase 1 clin trial have implications for further evaluation of ZPIV's imunisation schedule & use of concomitant vaccinations.''