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Effect of #ACE #Inhibitor and #ARB Initiation on Organ Support–Free Days in #Patients Hospitalized With #COVID19
A Randomized Clinical Trial - JAMA: https://jamanetwork.com/journals/jama/fullarticle/2803515?guestAccessKey=4694d866-267a-4a5d-9bbb-54479425c945&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=etoc&utm_term=041123
jamanetwork.comEffect of ACE Inhibitor and ARB Initiation on Organ Support–Free Days in Patients With COVID-19This randomized clinical trial examines the effect of initiation of a renin-angiotensin system inhibitor (ACE inhibitor or an angiotensin receptor blocker) on the composite outcome of hospital survival and organ support through 21 days in hospitalized patients with COVID-19.
''CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.''